P3a

• In active two-deviant oddball paradigms, the P3a is generated in response to the distractor

stimulus.

• The peak amplitude is a measure of focal attention, and has been shown to positively

correlate with executive function. The P3a latency reflects orientation to a non-target deviant

stimulus.

• Consistent with reports of decreased attention and executive function in

neuropsychological testing in subjects with mild AD, P3a amplitude is significantly reduced

in this population.